GETTING MY FRACTAL STORM (SELF-LAID TO WORK

While in the LSD-certain crystal construction, the facet chain from the lid residue L209EL2 forms substantial hydrophobic contacts with the two LSD and surrounding residues in TMs III, IV, and V (Figure 4C). If the lid moved apart to reveal the binding pocket in simulation, many of those contacts broke. We Hence hypothesized that L209EL2 acts as a